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Effects of cytarabine on glucoregulation in suckling rats
M Goto1, W P Zeller, R M Hurley
1Department of Pediatrics, Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois 60153.
Research Communications in Chemical Pathology and Pharmacology
|February 1, 1991
Abstract:
The effects of cytarabine (beta-cytosine arabinoside) on glucose metabolism is not well known. The present study showed that 5 mg/kg of cytarabine decreased plasma glucose level in 10 day old rat 4 hours after ip injection. Hepatic glycogenolysis decreased 4 hours after cytarabine injection. Thus, cytarabine alters newborn glucoregulation.