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Effect of chlorpromazine on the toxicity of doxorubicin in mice
H Shibata1, I Maekawa, S Furusawa
1Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Research Communications in Chemical Pathology and Pharmacology
|March 1, 1991
Abstract:
The effect of chlorpromazine (CPZ) on the toxicity of doxorubicin (DOX) were investigated in mice. CPZ significantly enhanced the acute toxicity and bone marrow toxicity induced by DOX. These results suggest the potentiation of DOX toxicity by CPZ is due to increase of sensitivity of mice to DOX.