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Related Experiment Video

Updated: Jun 13, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

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Methotrexate in rheumatoid arthritis.

Edwin Sl Chan¹, Patricia Fernandez, Bruce N Cronstein

¹New York University School of Medicine, Division of Clinical Pharmacology, Department of Medicine, 550 First Ave., New York, NY 10016, USA.

Expert Review of Clinical Immunology

|May 19, 2010

Summary

Methotrexate remains a key treatment for rheumatoid arthritis, with recent research clarifying its action and safety. Its value persists despite newer combination therapies.

Area of Science:

Rheumatology
Pharmacology

Background:

Methotrexate has been a primary therapy for rheumatoid arthritis for over 50 years.
Interest in methotrexate surged in the 1980s, leading to deeper understanding of its mechanisms and safety profile.
Combination therapies have not diminished methotrexate's importance in rheumatoid arthritis treatment.

Purpose of the Study:

To review the pharmacodynamics and pharmacokinetics of methotrexate.
To discuss the clinical applications of methotrexate as an anti-inflammatory and disease-modifying agent in rheumatoid arthritis.

Main Methods:

Literature review of pharmacodynamics and pharmacokinetics.
Analysis of clinical applications in rheumatoid arthritis therapy.

Main Results:

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Methotrexate's anti-inflammatory and disease-modifying properties are well-established.
Understanding of methotrexate's mechanisms of action and safety has advanced significantly.
Methotrexate remains a valuable agent, even with the advent of combination therapies.

Conclusions:

Methotrexate continues to be a cornerstone therapy for rheumatoid arthritis.
Its established efficacy and safety profile support its ongoing use.
Further insights into its action enhance its clinical application.