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Updated: Jun 13, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
In vitro tests of T cell-mediated drug hypersensitivity
Andreas Beeler1, Werner J Pichler
1Clinic of Rheumatology and Clinical Immunology/Allergology, Division of Allergology, Inselspital, 13010 Bern, Switzerland. andreas.beeler@allergy.unibe.ch
Abstract:
Allergic side-effects of drugs are a major problem of drug therapy. Diagnosis of drug-hypersensitivity reactions in patient is still very difficult as a broad spectrum of different drugs can elicit various immune-mediated diseases with distinct pathomechanisms. In this review, we summarize current in vitro techniques with an emphasis on diagnosis of T cell- mediated drug allergies and discuss recent research finding that may be applied to develop tests allowing for a better diagnosis of drug hypersensitivity in the future.
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