Concurrent use of antioxidants in cancer therapy: an update

Some chemotherapeutic agents and all radiation therapy generates reactive oxygen species (ROS), which induce apoptosis in cancer cells. As ROS play a role in drug-induced apoptosis, one might suspect that antioxidants may inhibit ROS and prevent apoptosis of cancer cells. In order to find an answer to whether or not there is any interference between the concurrent use of antioxidants and chemotherapeutic agents, we have reviewed all of the recent available literature. Except for three specific interferences, considerable data exists demonstrating an increased effectiveness, as well as decreased side effects of chemotherapeutic agents when administered with antioxidants.