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Updated: Jun 13, 2026
10:10
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
Development of autoimmunity in lymphoma
1Department of Hematology, Centre Henri Becquerel, 76000 Rouen, France. fabrice.jardin@rouen.fnclcc.fr
Expert Review of Clinical Immunology
|May 19, 2010
Summary
Lymphoma can trigger autoimmune diseases, presenting as skin, blood, rheumatic, or kidney issues. Monoclonal antibodies show promise for treating these immune disorders in lymphoma patients.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- Autoimmune diseases can develop alongside lymphoproliferative disorders.
- Autoimmunity may indicate a shared underlying process with lymphoma.
- Understanding this link is crucial for diagnosis and treatment.
Purpose of the Study:
- To review autoimmune manifestations associated with non-Hodgkin's and Hodgkin's lymphoma.
- To explore specificity based on lymphoma subtype.
- To discuss the physiopathological significance of these manifestations.
Main Methods:
- Literature review of autoimmune manifestations in lymphoma patients.
- Analysis of prevalence across different lymphoma subtypes.
- Discussion of proposed physiopathological mechanisms.
Main Results:
- Autoimmune manifestations are observed in all lymphoma subtypes.
- Marginal-zone lymphoma and T-cell lymphoma show higher prevalence.
- Common manifestations include skin, hematological, rheumatic, and renal diseases.
Conclusions:
- Autoimmunity and lymphoma may be interconnected processes.
- Mechanisms involve autoantibodies, loss of tolerance, Fas/Fas-ligand pathway, and chronic antigenic stimulation.
- Monoclonal antibodies offer a promising treatment avenue for lymphoma-related immune disorders.
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