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Related Concept Videos

Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Upper Respiratory Drugs: First and Second-Generation Antihistamines01:15

Upper Respiratory Drugs: First and Second-Generation Antihistamines

Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Related Experiment Video

Updated: Jun 13, 2026

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Desloratadine for allergic rhinitis.

Jeffrey A Wilken1, Adrian F Daly, Cynthia L Sullivan

  • 1Veterans Affairs Medical Center, Washington, DC 20422, USA. jeffrey.wilken@med.va.gov

Expert Review of Clinical Immunology
|May 19, 2010
PubMed
Summary
This summary is machine-generated.

Desloratadine effectively treats seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR) symptoms, including congestion. This non-sedating antihistamine offers 24-hour relief without impairing performance or causing cardiovascular issues.

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Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Area of Science:

  • Allergy and Immunology
  • Pharmacology

Background:

  • Seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR) impact up to 40% of the population, causing significant morbidity and reduced quality of life.
  • Antihistamines are a primary treatment, with non-sedating options preferred over older sedating drugs.

Purpose of the Study:

  • To review the efficacy and safety of desloratadine for treating SAR and PAR.
  • To highlight desloratadine's role as a first-line antihistamine therapy.

Main Methods:

  • Review of clinical trials and scientific literature on desloratadine.
  • Evaluation of desloratadine's effectiveness in relieving nasal and non-nasal allergic rhinitis symptoms.

Main Results:

  • Desloratadine is a non-sedating, non-impairing antihistamine effective for SAR and PAR symptom relief, including nasal congestion.
  • It provides 24-hour symptom control with once-daily dosing, addressing morning symptoms.
  • Clinical trials show no performance impairment, cardiovascular effects, or significant drug interactions.

Conclusions:

  • Desloratadine is a valuable therapeutic option for managing SAR and PAR.
  • Its favorable safety profile and efficacy support its use in allergic rhinitis treatment.