Related Experiment Video
Updated: Jun 13, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Autoimmune hepatitis in children: diagnosis, pathology and treatment
Walter Eb Sipe1, Philip Rosenthal
1University of California, Division of Pediatric Gastroenterology, Hepatology and Nutrition, 500 Parnassus Avenue, Box 0136, San Francisco, CA 94143-0136, USA. sipew@peds.ucsf.edu
Abstract:
Autoimmune hepatitis (AIH) is characterized by progressive inflammation of the liver and destruction of liver parenchyma. Rare in absolute terms, it is nevertheless an important cause of noninfectious chronic liver disease in children. In many ways, the diagnosis and treatment of children with AIH has changed little over the last 10 years. However, in recent years, steady progress in defining the genetic, immunologic and potential environmental triggers that underlie this disease, in addition to increasing experience with a wider array of therapeutic agents, promises to expand our understanding and ability to treat AIH effectively. This review will summarize the current clinical and pathophysiological understanding of AIH in children, along with therapeutic options.
Related Concept Videos
Hepatitis
Viral Hepatitis I: Introduction
Type I Diabetes I: Introduction
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

