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Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

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Related Experiment Video

Updated: Jun 13, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Asthma and autoimmunity: a complex but intriguing relation.

Alberto Tedeschi1, Riccardo Asero

  • 1Allergy and Clinical Immunology Unit, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Fondazione IRCCS, Via Pace, 9, 20122 Milano, Italy. albited@alice.it

Expert Review of Clinical Immunology
|May 19, 2010
PubMed
Summary

Asthma may involve autoimmune mechanisms, evidenced by autoantibodies and reactions to self-serum in some patients. This suggests potential autoimmune triggers for airway inflammation, even in allergic asthma.

Related Experiment Videos

Last Updated: Jun 13, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Area of Science:

  • Immunology
  • Pulmonology
  • Autoimmunity

Background:

  • Asthma and autoimmune diseases share immune system involvement.
  • Epidemiological studies link asthma with Type 1 diabetes, a classic autoimmune disease.
  • Experimental findings suggest autoimmune mechanisms may contribute to asthma pathogenesis.

Purpose of the Study:

  • To explore the potential autoimmune basis of asthma.
  • To investigate evidence supporting autoreactive mechanisms in both allergic and nonallergic asthma.
  • To examine the role of autoantibodies and autoantigens in asthma development.

Main Methods:

  • Analysis of epidemiological data linking asthma and autoimmune diseases.
  • Assessment of autoantibodies (antinuclear, anti-bronchial, anti-endothelial) in nonallergic asthma patients.
  • Intradermal skin testing with autologous serum in nonallergic asthma patients.
  • Evaluation of experimental animal models for autoreactive mechanisms in allergic asthma.

Main Results:

  • Nonallergic asthma shows female preponderance and increased autoantibodies.
  • About 50% of nonallergic asthma patients react to autologous serum, indicating circulating vasoactive factors.
  • Experimental models suggest human alpha-nascent polypeptide-associated complex acts as an IgE-reactive autoantigen, inducing allergic reactions and airway inflammation.
  • Response to immunosuppressive drugs indirectly supports the autoimmune hypothesis.

Conclusions:

  • Asthma is a heterogeneous condition with possible autoreactive/autoimmune triggers.
  • Autoimmune mechanisms may play a role in both nonallergic and allergic asthma.
  • Further research into the autoimmune basis of asthma is warranted.