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Updated: Jun 13, 2026
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Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
Recent insights into CD4+ T-cell specificity and function in type 1 diabetes.
Stuart I Mannering1, Thomas C Brodnicki
1Autoimmunity & Transplantation Division, The Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia. mannering@wehi.edu.au
Expert Review of Clinical Immunology
|May 19, 2010
Summary
Type 1 diabetes involves T-cell destruction of pancreatic beta-cells. Research highlights CD4(+) T-cells
Area of Science:
- Immunology
- Endocrinology
- Autoimmunity
Background:
- Type 1 diabetes (T1D) results from autoimmune destruction of pancreatic beta-cells.
- CD4(+) T cells are implicated in both the development and potential prevention of T1D.
- Understanding T-cell subsets, regulatory and effector, is key to T1D research.
Purpose of the Study:
- To review advances in understanding CD4(+) T-cell responses in Type 1 diabetes.
- To focus on human studies examining T-cell roles in T1D.
- To highlight new insights into T-cell specificity and function.
Main Methods:
- Review of human studies and immunological evidence.
- Analysis of genetic and immunological data.
- Discussion of newly identified T-cell antigens and epitopes.
Main Results:
- CD4(+) T cells are critical in T1D pathogenesis and prevention.
- New antigens and epitopes recognized by CD4(+) T cells in T1D patients have been identified.
- Knowledge of T-cell specificity and function is advancing.
Conclusions:
- Advances in understanding CD4(+) T-cell responses are crucial for T1D research.
- Developing new assays for analyzing islet antigen-specific CD4(+) T cells is progressing.
- Further research into CD4(+) T-cell roles offers therapeutic potential for T1D.
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