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Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs
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Published on: June 17, 2016

Circulating progenitor cells in chronic lung disease.

Borna Mehrad1, Michael P Keane, Brigitte N Gomperts

  • 1University of Virginia, Division of Pulmonary & Critical Care Medicine, Department of Medicine, Box 800546, Charlottesville, VA 22908, USA. mehrad@virginia.edu

Expert Review of Respiratory Medicine
|May 19, 2010
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Summary

Adult circulating progenitor cells from bone marrow contribute to lung repair and disease. Understanding their recruitment via chemokine signals is key for treating chronic lung disorders like asthma.

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Area of Science:

  • Pulmonary Medicine
  • Regenerative Medicine
  • Cell Biology

Background:

  • Tissue regeneration and repair are crucial for lung recovery from injury.
  • Chronic lung diseases often involve complex pathological processes affecting lung structure.
  • Adult progenitor cells are key players in lung repair, originating from lung tissue or bone marrow.

Purpose of the Study:

  • To review the biology of adult circulating progenitors in the context of lung disease.
  • To highlight the role of bone marrow-derived cells in lung regeneration.
  • To discuss chemokine-mediated recruitment of these cells to the lung.

Main Methods:

  • Literature review of studies on adult progenitor cells and lung repair.
  • Analysis of research on bone marrow-derived cells in lung tissue.
  • Examination of data on chemokine ligand-receptor interactions in lung inflammation.

Main Results:

  • Bone marrow-derived circulating cells can differentiate into lung epithelial and mesenchymal cells.
  • Specific chemokine pathways are involved in recruiting these cells to the lung.
  • These cells are implicated in the pathogenesis of asthma and interstitial lung diseases.

Conclusions:

  • Adult circulating progenitors, particularly those from bone marrow, are vital for lung repair mechanisms.
  • Understanding cell recruitment pathways is essential for developing therapies for chronic lung conditions.
  • Further research into these progenitor cells can offer new therapeutic strategies for lung diseases.