Related Experiment Video

Updated: Jun 13, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

Lung microRNA: from development to disease

Serge Patrick Nana-Sinkam1, Todd Karsies, Brent Riscili

  • 1Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, 201 Davis Heart and Lung Research Institute, 473 West 12th Avenue, Ohio State University, Columbus, OH 43210, USA. patrick.nana-sinkam@osumc.edu

Expert Review of Respiratory Medicine
|May 19, 2010
PubMed

Insights

MicroRNAs (miRNAs) are crucial in lung development and immune function. Their dysregulation contributes to lung diseases like cancer and sepsis.

Area of Science:

  • Molecular Biology
  • Pulmonology
  • Immunology

Background:

  • MicroRNAs (miRNAs) are increasingly recognized for their roles in various human diseases.
  • Their specific involvement in lung disease pathogenesis remains largely unexplored.
  • Evidence suggests miRNAs impact lung development and immune responses.

Purpose of the Study:

  • To investigate the role of miRNAs in lung development and disease.
  • To explore how miRNA dysregulation contributes to lung pathologies.
  • To review miRNA involvement in lung cancer, sepsis, and smoking-related lung disease.

Main Methods:

  • Review of existing murine models of lung disease.
  • Analysis of studies on bacterial challenges and miRNA expression.
  • Literature review focusing on miRNA involvement in specific lung diseases.

Main Results:

  • Loss of specific miRNAs is critical for lung development and immune modulation.
  • Bacterial infections can alter the expression of certain miRNAs.
  • miRNA dysregulation is implicated in lung cancer, sepsis, and smoking-related lung disease.

Conclusions:

  • miRNAs play a vital role in normal lung development and immune homeostasis.
  • Aberrant miRNA expression (dysregulation or reactivation) is a potential driver of lung disease.
  • Further research into miRNAs could reveal novel therapeutic targets for lung conditions.

More Related Videos

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...