Related Experiment Video
Updated: Jun 13, 2026
09:06
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
Lung microRNA: from development to disease
Serge Patrick Nana-Sinkam1, Todd Karsies, Brent Riscili
1Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, 201 Davis Heart and Lung Research Institute, 473 West 12th Avenue, Ohio State University, Columbus, OH 43210, USA. patrick.nana-sinkam@osumc.edu
Expert Review of Respiratory Medicine
|May 19, 2010
Summary
MicroRNAs (miRNAs) are crucial in lung development and immune function. Their dysregulation contributes to lung diseases like cancer and sepsis.
Area of Science:
- Molecular Biology
- Pulmonology
- Immunology
Background:
- MicroRNAs (miRNAs) are increasingly recognized for their roles in various human diseases.
- Their specific involvement in lung disease pathogenesis remains largely unexplored.
- Evidence suggests miRNAs impact lung development and immune responses.
Purpose of the Study:
- To investigate the role of miRNAs in lung development and disease.
- To explore how miRNA dysregulation contributes to lung pathologies.
- To review miRNA involvement in lung cancer, sepsis, and smoking-related lung disease.
Main Methods:
- Review of existing murine models of lung disease.
- Analysis of studies on bacterial challenges and miRNA expression.
- Literature review focusing on miRNA involvement in specific lung diseases.
Main Results:
- Loss of specific miRNAs is critical for lung development and immune modulation.
- Bacterial infections can alter the expression of certain miRNAs.
- miRNA dysregulation is implicated in lung cancer, sepsis, and smoking-related lung disease.
Conclusions:
- miRNAs play a vital role in normal lung development and immune homeostasis.
- Aberrant miRNA expression (dysregulation or reactivation) is a potential driver of lung disease.
- Further research into miRNAs could reveal novel therapeutic targets for lung conditions.
Related Concept Videos
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
02:39lncRNA - Long Non-coding RNAs
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...