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Updated: Aug 14, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
[Malherbe's calcifying epithelioma (pilomatrixoma) of the head and neck]
J M Aguirre1, J L Lopez Cedrun, R Martinez-Conde
1Département de Stomatologie, Université du Pays Basque, Vizcaya, Espagne.
Abstract:
Calcifying Epitheliomas of Malherbe (Pilomatrixomas) are benign tumors that have their origin in the hair matrix and clinically resemble a hard subcutaneous swelling. Most of these tumors are placed in the head and neck region, in our sample the Pilomatrixomas of this location were 49.6% of the total. The middle age of presentation of this tumor were 32.2 years, with two main peaks of incidence below 20 years and under 50. The most frequent locations were the auricular, cervical, ciliar, frontal, and temporal regions, with one case of multiple location. The middle size of the tumor in our sample was 1.2 cm. In this paper we review the main pathologic, clinic and therapeutic features of this lesion in the head and neck region.
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