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Updated: Jun 13, 2026
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Published on: November 5, 2020
Assessment of soluble angiogenic markers in pancreatic cancer
Cristiana Pistol-Tanase1, Elena Raducan, Simona Olimpia Dima
1'Victor Babes' National Institute of Pathology, 99-101 Splaiul Independentei, Bucharest, Romania. bioch@vbabes.ro.
Unlabelled:
Angiogenic markers such as VEGF/basic FGF (bFGF) can enlarge the diagnostic biomarkers panel for pancreatic cancer.
Materials & Methods:
Serum samples from 32 stage I-IV pancreatic cancer patients and 20 controls were analyzed for soluble VEGF/bFGF by ELISA and xMAP array.
Results:
VEGF/bFGF serum levels were significantly increased in patients compared with controls (p < 0.0001). We report a correlation with tumor diameter (p < 0.01/p < 0.05), stage (p < 0.001), Ki67LI (p < 0.005/p < 0.05) and carbohydrate 19-9 antigen (p < 0.005/p < 0.001). VEGF/bFGF levels analyzed by xMAP array were comparable with the pattern (patient/control) outline obtained by ELISA tests. We obtained a good correlation between these two soluble angiogenic markers (p < 0.001).
Conclusion:
Data obtained for angiogenic markers qualifies them as important candidates in the pancreatic cancer biomarker panel.
