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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: Jun 13, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Celiac sprue: a unique autoimmune disorder.

Shadi Rashtak1, Eric V Marietta, Joseph A Murray

  • 1Division of Medicine, Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Expert Review of Clinical Immunology
|May 19, 2010
PubMed
Summary

Celiac sprue (CS), an autoimmune disorder, frequently co-occurs with other autoimmune conditions affecting various organ systems. A gluten-free diet may help manage these associated autoimmune comorbidities.

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Area of Science:

  • Immunology
  • Gastroenterology
  • Endocrinology

Background:

  • Celiac sprue (CS) is a gluten-sensitive enteropathy characterized by autoimmune features.
  • CS affects multiple organs via immune and nonimmune pathways.
  • CS is often linked with other autoimmune disorders.

Purpose of the Study:

  • To review the co-occurrence of celiac sprue with autoimmune disorders across multiple organ systems.
  • To discuss the types and prevalence of autoimmune disorders associated with CS.
  • To explore potential mechanisms and the impact of a gluten-free diet on these comorbidities.

Main Methods:

  • Literature review of studies on celiac sprue and associated autoimmune disorders.
  • Analysis of co-occurrence across cutaneous, nervous, endocrine, musculoskeletal, gastrointestinal, and cardiovascular systems.
  • Examination of prevalence data and underlying mechanisms.

Main Results:

  • Celiac sprue is frequently associated with autoimmune disorders in various systems.
  • The review details specific autoimmune conditions linked to CS.
  • Prevalence of CS in other autoimmune disorders is also examined.

Conclusions:

  • Celiac sprue exhibits significant overlap with a wide range of autoimmune diseases.
  • Understanding these associations is crucial for comprehensive patient management.
  • A gluten-free diet shows potential therapeutic benefits for autoimmune comorbidities in CS patients.