Occupational asthma: risk factors, diagnosis and preventive measures

In adulthood, new or recurrent asthma is caused by work in approximately 10% of cases. The term occupational asthma is reserved for those cases arising from respiratory hypersensitivity to a specific workplace agent; in others (work-exacerbated asthma) the mechanism is of nonspecific airway irritation on a background of bronchial hyper-reactivity. Some 300 workplace agents are capable of inducing asthma de novo; fortunately, most cases are attributed to a much smaller number to which exposure occurs in a few high-risk occupations. Exposure level is the most important remediable risk factor; the factors governing individual susceptibility are poorly understood. Diagnosis is generally straightforward. Management is rarely pharmacologic and often difficult since the diagnosis incurs important employment and other social consequences.