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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

Chemokines, chemokine receptors and CD4+CD25+ regulatory T cells

Huanfa Yi1, Yong Zhao

  • 1Chinese Academy of Sciences, Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Beijing, China. yihf@ioz.ac.cn

Expert Review of Clinical Immunology
|May 19, 2010
PubMed

The fields of regulatory T (Treg) cells and chemokines/chemokine receptors have progressed rapidly in the last few years. Treg cells, especially CD4(+)CD25(+) Treg cells, play a critical role in maintaining self-tolerance and immune homeostasis. Chemokines and chemokine receptors are crucial for lymphoid development, homing and immunological regulation. This review will discuss the biological effects of chemokines and chemokine receptors on regulating the migration and development of CD4(+)CD25(+) Treg cells, and the potential clinical implications of these findings when considering chemokine receptors as therapeutic targets.

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