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Published on: December 15, 2011
Celiac disease: from gluten to skin
Ludovico Abenavoli1, Ilaria Proietti, Vincenzo Zaccone
1Department of Experimental and Clinical Medicine, University 'Magna Graecia', Viale Europa, 88100, Catanzaro, Italy. l.abenavoli@unicz.it
Expert Review of Clinical Immunology
|May 19, 2010
Summary
Celiac disease (CD) is an autoimmune disorder impacting the intestines. This review explores the link between CD and various skin conditions, highlighting potential diagnostic opportunities.
Area of Science:
- Gastroenterology and Dermatology
Background:
- Celiac disease (CD) is an autoimmune enteropathy triggered by gluten, leading to intestinal villous atrophy.
- CD is frequently linked with extraintestinal manifestations, including a growing number of dermatological conditions.
Purpose of the Study:
- To comprehensively review all skin manifestations associated with celiac disease reported in scientific literature.
- To analyze the potential underlying mechanisms connecting celiac disease and skin disorders.
- To discuss the clinical implications for diagnosing CD in patients presenting with skin conditions.
Main Methods:
- Systematic literature review of studies reporting skin manifestations in celiac disease patients.
- Analysis of immunological, gastrointestinal, and hormonal factors potentially linking CD and skin diseases.
- Discussion of diagnostic approaches for celiac disease in dermatology patients.
Main Results:
- Numerous skin diseases have been identified as extraintestinal manifestations of celiac disease.
- Potential mechanisms include impaired nutrient absorption, altered gut motility, and immune dysregulation.
- The association suggests a need for increased awareness among dermatologists regarding CD screening.
Conclusions:
- Skin manifestations are significant extraintestinal signs of celiac disease.
- Understanding these associations can improve early diagnosis and management of CD.
- Evaluating for celiac disease in patients with specific skin disorders is clinically relevant.
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