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Related Concept Videos

Fixation and Sectioning01:03

Fixation and Sectioning

Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens.
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
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In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
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A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...

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Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells
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Biological internal fixation: its background, methods, requirements, potential and limits.

S M Perren1

  • 1AO Research Institute, Davos Platz, Switzerland.

Acta Chirurgiae Orthopaedicae Et Traumatologiae Cechoslovaca
|May 19, 2010
PubMed
Summary
This summary is machine-generated.

Biological internal fixation prioritizes bone viability for enhanced healing and infection resistance. This approach, focusing on preserving blood supply, offers significant biological advantages over traditional methods.

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Area of Science:

  • Orthopedic Surgery
  • Biomaterials Science
  • Bone Biology

Background:

  • Surgical fracture treatment advanced with stable internal fixation, enabling early mobility.
  • Early focus on biomechanics in fixation overlooked biological factors crucial for healing and infection resistance.

Purpose of the Study:

  • To introduce and define biological internal fixation as a surgical approach.
  • To highlight the development of implant technology for flexible biological internal fixation.

Main Methods:

  • Surgical techniques prioritizing bone tissue viability and undisturbed blood supply.
  • Development of advanced implant technologies for flexible internal fixation.

Main Results:

  • Biological internal fixation reduces severe biological complications, such as infection and necrosis.
  • This method achieves reliable bone and soft tissue healing with improved local resistance to infection.

Conclusions:

  • Biological internal fixation represents a significant advancement in fracture treatment, emphasizing tissue viability.
  • While prioritizing biological outcomes, it acknowledges the continued need for conventional techniques in specific cases like necrotic bone.