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Related Experiment Video

Updated: Jun 13, 2026

Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
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Published on: October 2, 2017

The chemical MUPpeteer.

Ivan Rodriguez1

  • 1Department of Zoology and Animal Biology, National Research Center Frontiers in Genetics, University of Geneva, Geneva, Switzerland. ivan.rodriguez@unige.ch

Cell
|May 19, 2010
PubMed
Summary

Rodents display innate fear when detecting predator chemical cues. Major urinary proteins (Mups) from predators activate sensory neurons in the mouse vomeronasal organ, initiating a fear response.

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Olfactory Signaling

Background:

  • Rodents possess an innate fear response to predator chemical cues.
  • The vomeronasal organ (VNO) in mice is crucial for detecting social and predator-related chemical signals.
  • Major urinary proteins (Mups) are volatile compounds found in mammalian urine.

Discussion:

  • Papes et al. (2010) identified Major Urinary Proteins (Mups) as key olfactory triggers for innate fear in rodents.
  • These Mups are detected by specific sensory neurons within the mouse vomeronasal organ.
  • The VNO's role extends beyond pheromone detection to include the sensing of predator-derived fear-inducing molecules.

Key Insights:

  • Specific Major Urinary Proteins (Mups) act as direct olfactory cues for predator recognition.

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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
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  • Activation of the vomeronasal organ by Mups elicits an innate fear-like behavior in mice.
  • This research links specific urinary proteins to the innate fear circuitry in rodents.

    • Outlook:

    • Further research can explore the specific Mup "signatures" of different predator species.
    • Investigating the downstream neural pathways activated by Mup detection in the VNO.
    • Understanding Mup-mediated fear responses could inform conservation strategies and pest control methods.