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Related Concept Videos

Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: Jun 13, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Inflammatory bowel disease.

Eva Szigethy1, Laura McLafferty, Alka Goyal

  • 1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. szigethye@upmc.edu

Child and Adolescent Psychiatric Clinics of North America
|May 19, 2010
PubMed
Summary

Pediatric inflammatory bowel disease (IBD) often leads to psychological distress like anxiety and depression. Interventions can help children and adolescents cope, but their impact on IBD itself requires more research.

Area of Science:

  • Pediatric Gastroenterology
  • Child and Adolescent Psychiatry
  • Psychosomatic Medicine

Background:

  • Pediatric inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, presents significant medical challenges.
  • Young individuals with IBD frequently experience psychological and psychosocial difficulties, including high rates of depression and anxiety.
  • The etiology of these psychological issues is multifactorial, involving IBD-related factors (cytokines, steroid treatments) and psychosocial stress.

Purpose of the Study:

  • To review the etiology, clinical characteristics, and treatment of pediatric IBD.
  • To examine the psychological and psychosocial sequelae associated with IBD in children and adolescents.
  • To discuss empirically supported interventions for managing these challenges.

Main Methods:

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A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Investigating Intestinal Inflammation in DSS-induced Model of IBD

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Chronic Salmonella Infection Induced Intestinal Fibrosis

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Investigating Intestinal Inflammation in DSS-induced Model of IBD

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  • Literature review of studies on pediatric IBD.
  • Analysis of the interplay between IBD, its treatments, and psychological outcomes.
  • Evaluation of the evidence for various psychological interventions.

Main Results:

  • Pediatric IBD is linked to substantial medical morbidity and significant psychological distress.
  • Depression and anxiety are common, stemming from both disease-related biological factors and psychosocial stressors.
  • Interventions like cognitive behavioral therapy and educational resources show promise in improving mental health and quality of life.

Conclusions:

  • Psychological and psychosocial support is crucial for children and adolescents with IBD.
  • Current interventions effectively address anxiety and depression, enhancing health-related quality of life.
  • Further research is needed to ascertain the effects of these interventions on IBD severity and disease course.