Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Limits at Infinity

Limits at Infinity

The function that decreases as the input becomes very large provides a clear example of how mathematical functions can behave at extreme values. When the input increases continuously, the output becomes smaller and smaller, getting closer to a particular fixed value. Although the output never actually reaches this value, it moves nearer to it without limit. This behavior is a fundamental concept in understanding how functions behave as the input grows indefinitely. The graphical representation...

Indeterminate Products

Indeterminate Products

Indeterminate forms also arise in the evaluation of limits involving products, particularly when one factor approaches zero while the other tends to positive or negative infinity. This situation, commonly described as a zero-times-infinity form, does not have an immediately interpretable outcome. Depending on how the factors behave relative to one another, the limit of such a product may be zero, infinite, or a finite nonzero value.Product Limits and Algebraic RewritingTo analyze limits of this...

Introduction to Infinite Series

Introduction to Infinite Series

An infinite series is the sum of an infinite sequence of terms. Instead of adding only a fixed number of values, the addition continues without end. To make sense of this process, mathematicians examine partial sums, which are running totals formed by adding the first few terms of the series. If these partial sums approach a fixed number, the infinite series is said to converge. If they do not approach a finite value, the series diverges.The water tank example illustrates convergence through...

Nuclear Transmutation

Nuclear Transmutation

Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed protons being...

Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

Atomic Nuclei: Larmor Precession Frequency

Atomic Nuclei: Larmor Precession Frequency

The earth's gravitational field produces a 'twisting force' perpendicular to the angular momentum of a spinning mass (such as a spinning top) that causes the mass to 'wobble' around the gravitational field axis in a phenomenon called precession. Similarly, the magnetic moment (μ) of a spinning nucleus precesses due to an external magnetic field directed along the z-axis. The precession of the magnetic moment vector about the magnetic field is called Larmor precession, and the angular frequency...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Early α-synuclein-mediated mitochondrial dysfunction in a human cell model of Parkinson's disease dementia.

Communications biology·2026

Same author

ZFTA-RELA ependymomas make itaconate to epigenetically drive fusion expression.

Nature·2026

Same author

Childhood brain tumors instruct cranial hematopoiesis and immunotolerance.

Nature genetics·2026

Same author

<i>H3K27M-</i> and <i>BRAF V600E</i>-Altered gliomas and glioneuronal tumors-clinico-pathologic and radiologic perspective in a cohort treated with targeted therapy.

Neuro-oncology advances·2025

Same author

Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models.

Nature genetics·2025

Same author

Author Correction: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas.

Nature communications·2025

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

Infinium Assay for Large-scale SNP Genotyping Applications

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

To infinium, and beyond!

Karen D Wright¹, Richard J Gilbertson

¹Department of Developmental Neurobiology and Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

|May 19, 2010

Summary

This summary is machine-generated.

Glioblastoma (GBM) is a deadly brain cancer. The Cancer Genome Atlas (TCGA) project offers a new integrated view of the GBM methylome, advancing our understanding of this aggressive disease.

More Related Videos

Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice

Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice

Published on: October 16, 2014

A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence (FUEL)

A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence (FUEL)

Published on: May 23, 2014

Related Experiment Videos

Last Updated: Jun 13, 2026

Infinium Assay for Large-scale SNP Genotyping Applications

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice

Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice

Published on: October 16, 2014

A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence (FUEL)

A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence (FUEL)

Published on: May 23, 2014

Area of Science:

Neuro-oncology
Genomics
Epigenetics

Background:

Glioblastoma (GBM) is an aggressive primary brain tumor with a poor prognosis.
Understanding the molecular underpinnings of GBM is crucial for developing effective therapies.

Discussion:

This study presents an integrated analysis of the glioblastoma methylome.
The findings contribute to a deeper comprehension of GBM's molecular landscape.
Leveraging data from The Cancer Genome Atlas (TCGA) project.

Key Insights:

Provides one of the first integrated views of the glioblastoma methylome.
Enhances the understanding of epigenetic alterations in GBM.
Highlights the importance of multi-omics data in cancer research.

Outlook:

Further research into the GBM methylome may reveal novel therapeutic targets.
Integrated genomic and epigenomic data can guide personalized treatment strategies.
Continued exploration of The Cancer Genome Atlas (TCGA) data is essential for advancing GBM research.