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Related Experiment Video

Updated: Jun 13, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Sleep disturbances decrease self-assessed quality of life in individuals who have undergone cystectomy.

Helena Thulin¹, Ulrika Kreicbergs, Hans Wijkström

¹Division of Clinical Cancer Epidemiology, Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden. Helena.Thulin@ki.se

The Journal of Urology

|May 19, 2010

Summary

Urinary diversion after cystectomy, particularly orthotopic neobladder, increases nocturnal leakage and sleep disruption, negatively impacting quality of life for bladder cancer patients.

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Last Updated: Jun 13, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Area of Science:

Urology
Oncology
Sleep Medicine

Background:

The optimal urinary diversion strategy post-cystectomy for bladder cancer remains debated.
Nocturnal urinary disturbances significantly affect patient well-being and quality of life.

Purpose of the Study:

To investigate nocturnal urinary disturbances and quality of life in patients following cystectomy with various urinary diversion methods.
To compare outcomes between orthotopic neobladder, noncontinent urostomy, and continent urostomy.

Main Methods:

A study-specific questionnaire assessed sleep disturbances, nocturnal leakage, and voiding frequency in 452 patients (30-80 years old) across 7 Swedish urological centers.
Data from 491 identified individuals were collected, with 92% response rate.
Outcome variables were dichotomized and analyzed using relative risks.

Main Results:

Patients with orthotopic neobladder experienced higher risks of nocturnal urinary leakage and voiding frequency compared to noncontinent urostomy or continent urostomy.
37% of orthotopic neobladder patients reported negative sleep effects, versus 22% (noncontinent urostomy) and 14% (continent urostomy).
A significant negative impact on quality of life was observed in 88% of patients with sleep disruption versus 65% without.

Conclusions:

Nocturnal urinary issues are a major concern for patients with urinary diversion, especially after orthotopic neobladder creation.
Disrupted sleep due to urinary diversion significantly diminishes overall quality of life.
Further research is needed to optimize urinary diversion techniques and mitigate nocturnal disturbances.