Related Experiment Video
Updated: Jun 13, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
fpocket: online tools for protein ensemble pocket detection and tracking
Peter Schmidtke1, Vincent Le Guilloux, Julien Maupetit
1Departament de Fisicoquimica and Institut de Biomedicina, Facultat de Farmacia, Universitat de Barcelona, 08028, Barcelona, Spain.
Abstract:
Computational small-molecule binding site detection has several important applications in the biomedical field. Notable interests are the identification of cavities for structure-based drug discovery or functional annotation of structures. fpocket is a small-molecule pocket detection program, relying on the geometric alpha-sphere theory. The fpocket web server allows: (i) candidate pocket detection--fpocket; (ii) pocket tracking during molecular dynamics, in order to provide insights into pocket dynamics--mdpocket; and (iii) a transposition of mdpocket to the combined analysis of homologous structures--hpocket. These complementary online tools allow to tackle various questions related to the identification and annotation of functional and allosteric sites, transient pockets and pocket preservation within evolution of structural families. The server and documentation are freely available at http://bioserv.rpbs.univ-paris-diderot.fr/fpocket.
Related Concept Videos
Protein-protein Interfaces
Protein-Protein Interfaces
Conservation of Protein Domains Over Different Proteins
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Protein Folding
Protein Folding
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Folding

