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Related Concept Videos

Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...

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Related Experiment Video

Updated: Jun 13, 2026

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

Sensory deficits and distributed hierarchical dysfunction in schizophrenia.

David I Leitman1, Pejman Sehatpour, Beth A Higgins

  • 1Schizophrenia Research Center, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd., Orangeburg, NY 10962, USA.

The American Journal of Psychiatry
|May 19, 2010
PubMed
Summary

Schizophrenia patients show auditory processing deficits, impacting higher-level cognition. Early sensory processing dysfunction significantly contributes to cognitive impairments in schizophrenia.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Schizophrenia is marked by cognitive deficits linked to widespread cortical dysfunction.
  • Auditory processing, involving event-related potentials like mismatch negativity (MMN) and P300, is crucial for cognition.

Purpose of the Study:

  • To investigate the relationship between lower-level auditory sensory processing and higher-level cognitive deficits in schizophrenia.
  • To examine the roles of mismatch negativity (MMN) and P300 in schizophrenia-related cognitive impairments.

Main Methods:

  • Event-related brain potentials (MMN and P300) were recorded from schizophrenia patients and healthy controls under standard and individualized auditory conditions.
  • Multiple regression analysis and structural equation modeling were used to assess relationships between measures.

Main Results:

  • Schizophrenia patients exhibited significant deficits in MMN and P300 generation compared to controls under standard conditions.
  • When auditory stimuli were individualized to match performance, MMN deficits were eliminated, and P300 deficits were reduced.
  • MMN amplitude and diagnostic group independently predicted reduced P300 amplitude, with MMN explained by auditory cortex activity.

Conclusions:

  • Impaired basic auditory sensory processing in schizophrenia contributes significantly to higher-order cognitive deficits.
  • Findings support hierarchical models of cognitive impairment in schizophrenia, aligning with neurochemical theories of the disorder.