Related Experiment Video
Updated: Jun 13, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
Published on: August 16, 2017
Selection mechanisms underlying high impact biomedical research--a qualitative analysis and causal model
Hilary Zelko1, Guilherme Roberto Zammar, Ana Paula Bonilauri Ferreira
1Department of Surgery, Duke University, Durham, North Carolina, United States of America.
High-impact research relies on researcher heuristics, peer feedback, communication skills, psychological traits, and leveraging serendipity. These factors create a system that can be optimized for broader scientific impact.
Area of Science:
- Biomedical Research
- Scientific Innovation
- Publication Impact
Background:
- Limited understanding of high-impact publication generation from researchers' viewpoints.
- Focus on identifying mechanisms behind consistent high-impact output by a select group of researchers.
Purpose of the Study:
- To explore researchers' perspectives on the mechanisms driving the development of high-impact publications.
- To identify factors contributing to the consistent production of influential scientific work.
Main Methods:
- Qualitative interviews with researchers known for high-impact publications.
- Grounded Theory approach for data analysis and model development.
- Translation of qualitative findings into a System Dynamics mathematical model.
Main Results:
- Identification of five key themes: researcher heuristics, positive peer/mentor feedback, effective communication, motivating psychological attributes, and the role of randomness/serendipity.
- Development of an explanation model integrating these themes to represent high-impact research generation.
- Observation that successful researchers actively leverage randomness and serendipity.
Conclusions:
- The identified mechanisms offer insights for developing research coaching programs.
- Proposed selection mechanism can inform policy models to enhance high-impact research broadly.
- Findings support optimizing research strategies for greater institutional and governmental impact.
Related Concept Videos
Mechanistic Models: Compartment Models in Individual and Population Analysis
Causality in Epidemiology
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Criteria for Causality: Bradford Hill Criteria - II
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Mechanistic Models: Overview of Compartment Models
