Related Experiment Video
Updated: Jun 12, 2026

06:43
Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
Published on: April 3, 2026
Gastrointestinal stromal tumor with hemoperitoneum masquerading as appendicitis
Todd A Worley1, Shabirhusain S Abadin, Elizabeth Revesz
1Department of Surgery, St Joseph Hospital, Chicago, Illinois 60657, USA.
International Surgery
|May 20, 2010
Summary
Gastrointestinal stromal tumors (GIST) are rare, often presenting with bleeding. A ruptured GIST mimicking appendicitis highlights a rare cause of hemoperitoneum.
Area of Science:
- Gastroenterology
- Oncology
- Radiology
Background:
- Gastrointestinal stromal tumors (GIST) are rare mesenchymal neoplasms.
- GIST incidence is 11-15 cases per million worldwide annually.
- Common GIST presentations include gastrointestinal hemorrhage, early satiety, and weight loss.
Observation:
- Multislice computed tomography (CT) is a key diagnostic tool for GIST.
- Hemoperitoneum resulting from a ruptured GIST is an uncommon clinical scenario.
- A patient presented with symptoms mimicking acute appendicitis.
Findings:
- The patient's right lower-quadrant pain and peritonitis were attributed to hemoperitoneum.
- The source of the hemoperitoneum was identified as a ruptured GIST originating from the ileum.
Implications:
- This case underscores the importance of considering GIST in the differential diagnosis of abdominal emergencies.
- Ruptured GIST can present atypically, mimicking common surgical conditions like appendicitis.
- Accurate and timely diagnosis through imaging is crucial for appropriate patient management.
Related Concept Videos
Appendicitis
Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Appendicitis-I: Introduction
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis-II: Diagnostic Studies and Management
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...