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Fooled by the fragments: masquerading microangiopathy

Samir Dalia1, Cannon Milani, Jorge Castillo

  • 1The Miriam Hospital, Providence, RI 02906, USA. sdalia@lifespan.org

Medicine and Health, Rhode Island
|May 21, 2010
PubMed
Summary

No abstract available in PubMed .

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

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