Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does chylomicronemia cause atherosclerosis?

T Murase1, M Okubo, M Hara

  • 1Department of Endocrinology and Metabolism, Okinaka Memorial Institute for Medical Research, Tokyo.

The Tohoku Journal of Experimental Medicine
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A case of intrascrotal hemangioma].

Hinyokika kiyo. Acta urologica Japonica·1992
Same author

Chromosome-sized DNA of Malassezia pachydermatis by pulsed-field gel electrophoresis.

The Journal of veterinary medical science·1992
Same author

Plasma thrombomodulin and alpha 2-plasmin inhibitor-plasmin complex are elevated in active systemic lupus erythematosus.

The Journal of rheumatology·1992
Same author

Effect of prolyl 4-hydroxylase inhibitor on fibroblast collagen production in vitro: an approach to the treatment of systemic sclerosis.

The Journal of rheumatology·1992
Same author

Unilateral dermatomal pigmentary dermatosis: a variant dyschromatosis?

Journal of the American Academy of Dermatology·1992
Same author

Delayed shortening and shrinkage of cochlear outer hair cells.

The American journal of physiology·1992
Same journal

Demographic and Geographical Distribution of Dentists in Japan: Analysis of National Data in 1996, 2006, and 2016.

The Tohoku journal of experimental medicine·2026
Same journal

Association of Myeloid Derived Suppressor Cells and Immunosuppressive Elements with Disease and Prognosis in Pancreatic Adenocarcinoma.

The Tohoku journal of experimental medicine·2026
Same journal

Reduced EphB2 Expression Due to Hypermethylation in DLBCL-NOS Is Associated with Prognosis.

The Tohoku journal of experimental medicine·2026
Same journal

Dynamic Expression of Podoplanin Correlates with Synovitis Severity in a Lipopolysaccharide-Induced Rabbit Arthritis Model.

The Tohoku journal of experimental medicine·2026
Same journal

Fifteen Years On: A Retrospective Institutional Case Study of Soma General Hospital Following the 2011 Fukushima Daiichi Nuclear Accident.

The Tohoku journal of experimental medicine·2026
Same journal

Optimizing Outcomes in ICU Pulmonary Infections: The Role of Comprehensive Nursing Intervention.

The Tohoku journal of experimental medicine·2026
See all related articles

Chylomicronemia, a condition of high blood lipids, does not cause atherosclerosis. Studies in guinea pigs showed no arterial wall changes despite induced chylomicronemia, indicating no predisposition to this cardiovascular disease.

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Pathology

Background:

  • Chylomicronemia is characterized by elevated levels of chylomicrons, a type of lipoprotein.
  • The potential link between chylomicronemia and atherosclerosis remains a significant clinical question.
  • Understanding this relationship is crucial for cardiovascular disease risk assessment.

Purpose of the Study:

  • To investigate whether chylomicronemia directly causes atherosclerosis.
  • To examine the arterial walls of animals with induced chylomicronemia for atherosclerotic changes.

Main Methods:

  • Experiments were conducted using guinea pigs lacking apolipoprotein CII, which naturally develop chylomicronemia on a high-fat diet.
  • Animals were maintained on a high-fat diet for 6-12 months.

Related Experiment Videos

  • Histopathological and ultrastructural examinations of the aorta and coronary arteries were performed.

    • Main Results:

    • No atherosclerotic changes were observed in the aorta or coronary arteries of any examined guinea pigs.
    • The arterial endothelium remained intact in all subjects.
    • Absence of lipid-laden foam cells and migrating cells within the arterial walls was noted.

    Conclusions:

    • Chylomicronemia does not appear to predispose individuals to the development of atherosclerosis.
    • These findings suggest that other factors may be more critical in the pathogenesis of atherosclerosis in the context of high chylomicron levels.