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Apparent isolated skin relapse in acute monocytic leukemia. A case report
L Pagano1, L M Larocca, M Zollino
1Istituto di Semeiotica Medica, Università Cattolica del Sacro Cuore, Roma, Italy.
Tumori
|April 30, 1991
Summary
This case study details acute monocytic leukemia with isolated skin relapse despite bone marrow remission. Treatment provided temporary regression, but the patient ultimately succumbed to the disease.
Area of Science:
- Hematology
- Oncology
- Dermatology
Background:
- Acute monocytic leukemia (AML) is a rare hematologic malignancy.
- Skin relapse in AML can present as an isolated finding.
Observation:
- A patient with acute monocytic leukemia presented with apparent isolated skin relapse.
- Bone marrow examination showed morphological remission, but cytogenetic analysis revealed relapse.
Findings:
- Treatment with daunorubicin, cytarabine, and thioguanine led to regression of skin lesions.
- The patient experienced a subsequent relapse and died within months, without achieving further remission.
Implications:
- This case highlights the complex relationship between cutaneous and medullary disease in AML.
- Understanding isolated skin relapse is crucial for effective AML management and prognosis.