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Review for disease of the year: immunopathogenesis of ocular sarcoidosis
Anita S Y Chan1, Om P Sharma, Narsing A Rao
1Doheny Eye Institute, California, USA.
Abstract:
Ocular sarcoidosis is a heterogeneous disease having varied presentations and severities with genetic susceptibility playing a role. Sarcoidosis is characterized by the presence of noncaseating (non-necrotizing) granulomas in the affected organs or tissue systems. What causes these granulomas is not known, but current knowledge of the immunology of this enigmatic disease centers on a CD4 T helper type 1 cell response. This review deals with immunologic sequences that lead to the formation of sarcoid granulomas and explores the immunopathogenesis of ocular inflammation seen in patients with sarcoidosis.
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