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Updated: Jun 12, 2026

Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
Intravitreal methotrexate as adjunctive, palliative therapy in intraocular T-cell lymphoma
Sanjeewa S Wickremasinghe1, Elvis Ojaimi, Lyndell Lim
1The Ocular Immunology Clinic, The Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
Purpose:
To report on the rapid and sustained effect following injection of intravitreal methotrexate (IVTMTX) in intraocular T-cell lymphoma.
Design:
Report of 2 cases.
Methods:
A young male with natural killer/T-cell lymphoma presented with infiltrative nodular iridocyclitis and received a single IVTMTX. An elderly female with peripheral T-cell lymphoma presented with a hypopyon, infiltrative iridocyclitis, and choroidal effusions and received 3 IVTMTX over 4 months.
Results:
Both patients responded well after the first injection, with resolution of signs within 1 week and improvement in vision.
Conclusions:
IVTMTX may be effective as a palliative, vision-restoring measure in patients with systemic T-cell lymphoma.
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