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Updated: Jun 12, 2026

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury
Published on: February 10, 2026
Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control
Orfeas Liangos1, Francesco Addabbo, Hocine Tighiouart
1Kidney & Dialysis Research Laboratory, St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA. liangos_o@hotmail.com
Background:
Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality.
Objective:
To evaluate the plasma profile of biomarkers potentially involved in AKI development following CPB.
Methods:
In a nested case-control study, plasma levels of 27 biomarkers in 11 AKI cases were compared with 25 controls.
Results:
Pre-CPB, plasma levels of epidermal growth factor and macrophage inflammatory protein-1beta, 2 h following CPB, soluble vascular cell adhesion molecule-1 (sVCAM-1), fractalkine and macrophage inflammatory protein-1alpha, and at later time points, sVCAM-1 and interleukin-6 were associated with AKI.
Conclusion:
Biomarkers associated with AKI following CPB may merit further study.
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