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Primary Sjögren's syndrome activity and damage indices comparison
1Santo António Hospital - Centro Hospitalar do Porto, Porto, Portugal.
European Journal of Clinical Investigation
|May 21, 2010
Summary
Comparing primary Sjögren's Syndrome outcome measures, this review highlights the EULAR SS Disease Activity Index (ESSDAI) as more accurate for activity changes. Further research is needed to validate these important tools for clinical trials.
Area of Science:
- Rheumatology
- Clinical Trials
- Patient Outcomes
Background:
- Primary Sjögren's Syndrome (pSS) assessment lacks standardized outcome measures.
- Significant variability exists in current tools for evaluating pSS patients.
- This review critically compares existing and proposed indices for pSS assessment.
Purpose of the Study:
- To compare proposed outcome measures for primary Sjögren's Syndrome.
- To evaluate activity and damage indices used in pSS research.
- To assess patient-reported outcome tools for pSS.
Main Methods:
- Analysis of three activity indices: SSDAI, SCAI, and ESSDAI.
- Evaluation of two damage indices: SSDDI and SSDI.
- Consideration of patient-reported outcome tools: PROFAD, SF-36, and ESSPRI.
Main Results:
- ESSDAI demonstrates higher accuracy in detecting activity changes compared to SSDAI and SCAI.
- Both activity and damage indices have limitations, including validity and content validity.
- Patient-reported outcome tools like ESSPRI complement global scores for subjective feature assessment.
Conclusions:
- Existing indices show potential utility but require larger studies for validation.
- Reliability, sensitivity to change, and clinical trial applicability need further assessment.
- Distinguishing between disease activity and damage, and defining flare, remain key challenges in pSS.
