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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Immune cells in uteroplacental tissues throughout pregnancy: a brief review

Gérard Chaouat1, Nathalie Ledée-Bataille, Sylvie Dubanchet

  • 1U 782 INSERM, Equipe implantation et dialogue cytokinique mère conceptus, 32 rue des Carnets et Hôpital Antoine Béclère Pavillon Jean Dalsace, 92141 Clamart France. Gerardchaouat@aol.com

Reproductive Biomedicine Online
|May 21, 2010
PubMed

In a brief introduction, this review states why the presence of immune cells at the interface poses problems for an immunologist (Medawar paradigm). Different types of placentation are then discussed, and the various interactions with leukocytes, the extreme being with the equids where a certain degree of 'attack' is often seen. The limits of animal models when dealing with the human situation are emphasized. It is then stated why the various phases of pregnancy are different, and an analysis made of the cellular movements at the implantation, peri-implantation, immediate post-implantation and resorption windows in rodents. Details of the cellular components involved are given, as are hints for the human situation. The Th1/Th2 paradigm is described, with clinical examples, and its limits. Thus, the newly appraised dual role of natural killer (NK) cells is discussed, with examples in rodents and in humans (pre-eclampsia, implantation failure, abortion systems). Clinical data on the IL-12 /IL-18/NK tripod and implantation failure in humans are detailed.

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