Related Experiment Video
Updated: Jun 12, 2026
08:56
In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay
Published on: May 5, 2020
NB-LRR proteins: pairs, pieces, perception, partners, and pathways
Timothy K Eitas1, Jeffery L Dangl
1Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
Current Opinion in Plant Biology
|May 21, 2010
Summary
Plant disease resistance relies on Nucleotide-binding site, Leucine-rich repeat (NB-LRR) proteins. Recent findings show two NB-LRRs can work together and specific protein fragments can trigger defense signaling.
Area of Science:
- Plant immunity
- Molecular biology
Background:
- Plant innate immune receptors, known as disease resistance (R) proteins, often possess a Nucleotide-binding site, Leucine-rich repeat (NB-LRR) structure.
- Understanding NB-LRR signaling is crucial for deciphering plant defense mechanisms against pathogens.
Purpose of the Study:
- To summarize recent advancements in NB-LRR signaling pathways in plants.
- To highlight novel findings regarding the cooperative function of NB-LRRs and the role of specific protein domains in initiating plant defense.
Main Methods:
- Review of recent scientific literature on NB-LRR signaling.
- Analysis of experimental data on protein-protein interactions and functional domains within NB-LRRs.
Main Results:
- An emerging theme indicates that pairs of NB-LRRs can collaborate to confer disease resistance against various pathogen isolates.
- Specific fragments of NB-LRR proteins have been identified as sufficient to trigger plant defense signaling pathways.
- Distinct functional fragments from different NB-LRR proteins demonstrate conserved capabilities in initiating defense responses.
Conclusions:
- NB-LRR proteins play a pivotal role in plant immunity, with cooperative action and specific functional domains being key to their efficacy.
- The identification of minimal functional fragments provides new insights into the molecular mechanisms of plant defense signaling.
- Accessory proteins and downstream host genes are increasingly recognized as important components modulating NB-LRR-mediated immunity.
Related Concept Videos
01:20Parallel Processing
The brain processes sensory information rapidly due to parallel processing, which involves sending data across multiple neural pathways at the same time. This method allows the brain to manage various sensory qualities, such as shapes, colors, movements, and locations, all concurrently. For instance, when observing a forest landscape, the brain simultaneously processes the movement of leaves, the shapes of trees, the depth between them, and the various shades of green. This enables a quick and...
01:19Interactions Between Signaling Pathways
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
02:26Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
02:26Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
00:49Ligand Binding and Linkage
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked. In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
01:30Assembly of Signaling Complexes
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...