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Updated: Jun 12, 2026

Assays for Validating Histone Acetyltransferase Inhibitors
09:11

Assays for Validating Histone Acetyltransferase Inhibitors

Published on: August 6, 2020

[Histone deacetylase inhibitors: highlight on epigenetic regulation]

N Pécuchet1, T Cluzeau, C Thibault

  • 1Groupe hospitalier Pitié-Salpêtrière, Service d'oncologie médicale, 75013 Paris, France.

Bulletin Du Cancer
|May 21, 2010
PubMed

Insights

Histone deacetylase (HDAC) inhibitors are epigenetic regulators showing anti-cancer potential by modulating gene expression. Clinical trials reveal promising results, especially in lymphomas and in combination therapies.

Area of Science:

  • Epigenetics and Gene Regulation
  • Molecular Biology
  • Cancer Biology

Context:

  • Histone deacetylases (HDACs) are key epigenetic regulators influencing DNA-histone interactions.
  • HDACs are involved in critical cellular processes including cell cycle control, apoptosis, and angiogenesis.
  • Dysregulation of HDACs is implicated in various cancers.

Purpose:

  • To review recent biological and clinical data on the anti-neoplastic role of HDAC inhibitors (HDACIs).
  • To highlight the therapeutic potential of HDACIs in cancer treatment.

Summary:

  • HDAC inhibitors (HDACIs) modulate gene expression, upregulating tumor suppressors and downregulating oncogenes.
  • HDACIs demonstrate efficacy in preclinical cancer models.
  • Clinical development shows promising results for HDACIs in lymphomas and in combination therapies for myeloma, lung cancer, and myeloid neoplasms.

Impact:

  • HDACIs represent a promising class of anti-cancer agents.
  • Combination strategies involving HDACIs may enhance therapeutic outcomes.
  • Further clinical investigation of HDACIs is warranted for various malignancies.

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