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Updated: Jun 12, 2026
10:46
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Modifiable factors influencing relapses and disability in multiple sclerosis
M B D'hooghe1, G Nagels, V Bissay
1National Center For Multiple Sclerosis, Melsbroek, Belgium. marie.dhooghe@ms-centrum.be
Multiple Sclerosis (Houndmills, Basingstoke, England)
|May 21, 2010
Summary
Lifestyle factors significantly impact multiple sclerosis (MS) course. While infections and stress may trigger relapses, pregnancy and vitamin D may reduce them. Smoking worsens MS progression.
Area of Science:
- Neurology
- Immunology
Background:
- The natural history of multiple sclerosis (MS) is influenced by various factors.
- Understanding these factors is crucial for managing MS progression and relapses.
Purpose of the Study:
- To review and synthesize evidence on factors influencing the course of multiple sclerosis.
- To identify triggers for relapses and factors affecting disease progression.
Main Methods:
- Literature review of studies examining lifestyle, environmental, and medical factors in multiple sclerosis.
- Analysis of evidence linking specific factors to relapse rates and disability progression.
Main Results:
- Infections, postpartum period, and stress can trigger MS relapses; vaccinations appear safe.
- Pregnancy, breastfeeding, sunlight, and vitamin D are associated with reduced relapse rates.
- Smoking significantly worsens MS progression; moderate alcohol and exercise may be neuroprotective.
Conclusions:
- Multiple lifestyle and environmental factors modify multiple sclerosis activity and progression.
- Identifying and modifying these factors may offer therapeutic strategies for MS management.
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