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Updated: Jun 12, 2026

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
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Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

Twenty-first century challenges for biomaterials.

Larry L Hench1, Ian Thompson

  • 1Department of Materials Science and Engineering, University of Florida, Gainesville, FL, USA. larryhench@embarqmail.com

Journal of the Royal Society, Interface
|May 21, 2010
PubMed
Summary

Biomaterials research, pioneered by Prof. Bill Bonfield, advanced skeletal prostheses by focusing on tissue interaction and mechanical properties. Early biomaterials prioritized inertness, evolving towards tailored bioactive materials for future challenges.

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Area of Science:

  • Biomaterials Science
  • Biomedical Engineering
  • Orthopedic Research

Background:

  • The field of biomaterials emerged in the 1960s-70s, focusing on materials for internal human use, termed prostheses.
  • Professor Bill Bonfield pioneered research into mechanical properties of tissues, particularly bone, for reliable skeletal prostheses.
  • Early biomaterial development aimed for tissue compatibility and minimal toxicity, with over 50 prostheses from 40 materials in clinical use by 1980.

Purpose of the Study:

  • To pay tribute to Professor Bill Bonfield's foundational contributions to bone biomechanics and biomaterials.
  • To summarize the evolution of biomaterials from inert to bioactive substances.
  • To highlight opportunities in tailoring biomaterial composition, texture, and surface chemistry for 21st-century challenges.

Main Methods:

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Accessing the Cytotoxicity and Cell Response to Biomaterials
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Last Updated: Jun 12, 2026

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
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  • Review of historical biomaterial development and applications.
  • Analysis of the shift from biologically inert to bioactive materials.
  • Exploration of interdisciplinary research in bone biomechanics and biomaterials.

Main Results:

  • The first generation of biomaterials focused on biological inertness and adaptations of existing commercial materials.
  • Over three million prosthetic parts were implanted annually by 1980, utilizing diverse materials.
  • Bonfield's work emphasized understanding tissue-material interactions for improved prostheses.

Conclusions:

  • Biomaterials have evolved significantly, moving beyond inertness towards tailored bioactive properties.
  • Interdisciplinary research, as exemplified by Bonfield, is crucial for advancing biomaterial science.
  • Future opportunities lie in optimizing biomaterial characteristics to address complex medical needs.