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Stabilizing capping motif for beta-hairpins and sheets.

Brandon L Kier1, Irene Shu, Lisa A Eidenschink

  • 1Department of Chemistry, University of Washington, Seattle WA 98195, USA.

Proceedings of the National Academy of Sciences of the United States of America
|May 21, 2010
PubMed
Summary

A novel beta-cap motif significantly enhances beta-hairpin peptide stability in water. This "unnatural" cap, using natural residues, reduces fraying and improves folding, outperforming disulfide bonds.

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