Related Experiment Video
Updated: Jun 12, 2026

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
Published on: May 12, 2019
Oral mucositis: the new paradigms
Douglas E Peterson1, Rajesh V Lalla
1Department of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine and Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, Connecticut 06030-1605, USA.
Recent research is advancing mucositis management beyond supportive care. New insights into symptom clusters, genetic risk, and advanced technologies pave the way for targeted prevention and treatment of mucosal injury.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Mucositis is a common, debilitating side effect of cancer therapy.
- Current management focuses on supportive care, not targeted prevention.
- A need exists for molecularly targeted interventions for mucositis.
Purpose of the Study:
- To review recent advances in understanding and managing mucositis.
- To highlight the convergence of molecular pathobiology with clinical approaches.
- To explore novel strategies for prevention and treatment of mucosal injury.
Main Methods:
- Review of current literature on mucositis.
- Emphasis on symptom cluster modeling.
- Integration of genetic risk, imaging, and computational biology.
Main Results:
- Symptom cluster modeling for mucositis is evolving.
- Genetic-based risk studies are emerging for prediction models.
- New imaging and computational technologies are driving insights.
Conclusions:
- Convergence of molecular pathobiology and advanced technologies.
- The field is poised for molecularly targeted drug development.
- Future efforts aim to develop targeted therapies for mucositis.
Related Concept Videos
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Peptic Ulcer Disease II: Pathophysiology
Peptic Ulcer Disease III: Clinical Manifestations and Complications
