Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic Value and Treatment Responsiveness of Ultrasonography Features in Correlation With Clinical Findings in Early Peripheral Spondyloarthritis.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Preventing MALT1-mediated CYLD cleavage induces intestinal dysbiosis and reduces EAE severity.

EMBO reports·2026
Same author

Structural and mechanistic insights into the constitutive Themis-Grb2 complex in T cell signalling.

Nature communications·2026
Same author

Efgartigimod in Sjögren's disease: a phase 2, randomised, placebo-controlled, parallel-group, double-blinded, proof-of-concept study (RHO).

Annals of the rheumatic diseases·2026
Same author

Barrier breakdown: insights into the skin-gut axis in psoriatic arthritis.

Trends in immunology·2026
Same author

In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development.

Cell reports·2026

Related Experiment Video

Updated: Jun 12, 2026

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis
04:47

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

Interactions between gut inflammation and arthritis/spondylitis.

Peggy Jacques1, Dirk Elewaut, Herman Mielants

  • 1Department of Internal Medicine, Rheumatology, University Hospital of Ghent, Ghent, Belgium.

Current Opinion in Rheumatology
|May 21, 2010
PubMed
Summary

Spondyloarthritis involves gut and joint inflammation. Animal models and human genetics reveal stromal cells and interleukin-23 receptor (IL-23R) as key factors in this gut-joint axis.

More Related Videos

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Related Experiment Videos

Last Updated: Jun 12, 2026

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis
04:47

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Area of Science:

  • Immunology
  • Genetics
  • Rheumatology

Background:

  • Spondyloarthritis (SpA) presents with concurrent gut and joint inflammation.
  • The anatomical connection between these inflamed sites remains unclear.
  • Understanding the gut-joint axis is crucial for SpA pathogenesis.

Purpose of the Study:

  • To review current evidence on the gut-joint axis in spondyloarthritis.
  • To explore the roles of stromal cells and genetic factors.
  • To highlight recent findings from animal models and human genetic studies.

Main Methods:

  • Review of animal models of spondyloarthritis.
  • Analysis of human genome-wide association studies (GWAS) for ankylosing spondylitis.
  • Examination of immunological signaling pathways, including TNFRI and IL-23R.

Main Results:

  • Stromal cells are implicated as critical players in the pathogenesis of SpA.
  • Tumor necrosis factor receptor 1 (TNFRI) signaling is sufficient for developing combined gut and joint inflammation in models.
  • Interleukin-23 receptor (IL-23R) emerged as a significant susceptibility locus for ankylosing spondylitis.

Conclusions:

  • Human genetic data and animal research offer new insights into the gut-joint axis in SpA.
  • The precise mechanisms by which identified genetic associations impact the immune environment require further investigation.
  • Elucidating these pathways is essential for advancing our understanding and treatment of SpA.