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Updated: Jun 12, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilic esophagitis.
1Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's, Hospital Medical Center, Cincinnati, OH, USA. phil.putnam@cchmc.org
Minerva Gastroenterologica E Dietologica
|May 21, 2010
Summary
Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory condition of the esophagus. Effective management involves long-term treatment with steroids or diet changes to prevent serious complications like strictures.
Area of Science:
- Gastroenterology
- Allergy Immunology
Background:
- Eosinophilic esophagitis (EoE) is a chronic inflammatory condition affecting the esophagus, increasingly recognized since the 1990s.
- EoE is characterized by eosinophilpredominant inflammation and is often linked to food allergies.
- Clinical presentation varies by age, with dysphagia common in adolescents and adults, and feeding issues or vomiting in younger children.
Purpose of the Study:
- To describe the prevalence, clinical features, and management of eosinophilic esophagitis.
- To highlight the diagnostic criteria and complications associated with EoE.
Main Methods:
- Review of endoscopic and histologic findings in EoE.
- Analysis of age-specific clinical manifestations.
- Evaluation of treatment outcomes for steroids and dietary antigen elimination.
Main Results:
- EoE is increasingly prevalent and associated with food allergies.
- Dysphagia is a primary symptom in older patients, while younger children may exhibit feeding difficulties.
- High recurrence rates necessitate indefinite treatment.
Conclusions:
- EoE requires long-term management strategies, including swallowed steroids or dietary antigen elimination.
- Untreated EoE can lead to esophageal fibrosis, strictures, and serious complications such as impaction and perforation.
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