Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Esophageal IgG4 levels correlate with histopathologic and transcriptomic features in eosinophilic esophagitis.

Allergy·2018
Same author

Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.

Mucosal immunology·2017
Same author

Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2016
Same author

Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing.

Genes and immunity·2014
Same author

Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis.

Mucosal immunology·2013
Same author

Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis.

Gut·2009
Same journal

Hepatic steatosis integrated approach: nutritional guidelines and joined nutraceutical administration.

Minerva gastroenterologica e dietologica·2021
Same journal

Diagnostic accuracy of computerized tomography (CT) angiography in detecting non-variceal gastrointestinal bleeding (NVGIB): a sistematic review.

Minerva gastroenterologica e dietologica·2020
Same journal

Helicobacter pylori and non-alcoholic fatty liver disease.

Minerva gastroenterologica e dietologica·2020
Same journal

Hypertriglyceridemic pancreatitis.

Minerva gastroenterologica e dietologica·2020
Same journal

Effectiveness of percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis.

Minerva gastroenterologica e dietologica·2020
Same journal

Noninvasive diagnosis of fibrosis in non-alcoholic fatty liver disease: diagnostic accuracy of different scores.

Minerva gastroenterologica e dietologica·2020
See all related articles

Related Experiment Video

Updated: Jun 12, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Eosinophilic esophagitis.

P E Putnam1

  • 1Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's, Hospital Medical Center, Cincinnati, OH, USA. phil.putnam@cchmc.org

Minerva Gastroenterologica E Dietologica
|May 21, 2010
PubMed
Summary
This summary is machine-generated.

Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory condition of the esophagus. Effective management involves long-term treatment with steroids or diet changes to prevent serious complications like strictures.

More Related Videos

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Related Experiment Videos

Last Updated: Jun 12, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Area of Science:

  • Gastroenterology
  • Allergy Immunology

Background:

  • Eosinophilic esophagitis (EoE) is a chronic inflammatory condition affecting the esophagus, increasingly recognized since the 1990s.
  • EoE is characterized by eosinophilpredominant inflammation and is often linked to food allergies.
  • Clinical presentation varies by age, with dysphagia common in adolescents and adults, and feeding issues or vomiting in younger children.

Purpose of the Study:

  • To describe the prevalence, clinical features, and management of eosinophilic esophagitis.
  • To highlight the diagnostic criteria and complications associated with EoE.

Main Methods:

  • Review of endoscopic and histologic findings in EoE.
  • Analysis of age-specific clinical manifestations.
  • Evaluation of treatment outcomes for steroids and dietary antigen elimination.

Main Results:

  • EoE is increasingly prevalent and associated with food allergies.
  • Dysphagia is a primary symptom in older patients, while younger children may exhibit feeding difficulties.
  • High recurrence rates necessitate indefinite treatment.

Conclusions:

  • EoE requires long-term management strategies, including swallowed steroids or dietary antigen elimination.
  • Untreated EoE can lead to esophageal fibrosis, strictures, and serious complications such as impaction and perforation.