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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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Animal Models of Depression - Chronic Despair Model (CDM)
05:47

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Published on: September 23, 2021

Circadian rhythms and depression.

Philip Boyce1, Erin Barriball

  • 1Discipline of Psychiatry, University of Sydney and Department of Psychiatry, Westmead Hospital, Sydney, New South Wales, Australia. philip.boyce@sydney.edu.au

Australian Family Physician
|May 21, 2010
PubMed
Summary
This summary is machine-generated.

Disruptions in circadian rhythms are linked to depression, offering novel treatment avenues. Therapies like bright light and social rhythm therapy can help manage these disruptions.

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Area of Science:

  • Psychiatry
  • Sleep Medicine
  • Chronobiology

Background:

  • Depression is a prevalent disorder frequently encountered in primary care settings.
  • Circadian rhythm disruptions are increasingly recognized as a significant factor in depression.
  • These disruptions present novel and promising therapeutic targets for depression management.

Purpose of the Study:

  • To discuss the relationship between circadian rhythms and depression.
  • To review nonpharmaceutical and pharmaceutical interventions aimed at modulating circadian rhythms.

Main Methods:

  • Literature review of studies on circadian rhythms and depression.
  • Analysis of interventions targeting circadian rhythm shifts.

Main Results:

  • Key indicators of circadian disturbance in depression include early morning awakening, diurnal mood variation, altered sleep architecture, and changes in core body temperature and cortisol rhythms.
  • Nonpharmaceutical interventions like Interpersonal and Social Rhythm Therapy (IPSRT) focus on stabilizing social cues and managing relationships.
  • Bright light therapy is effective for Seasonal Affective Disorders and may benefit other depressive conditions.
  • Agomelatine, an antidepressant, targets melatonergic receptors, influencing circadian regulation.

Conclusions:

  • Circadian rhythm disturbances are a notable feature of depression, manifesting in various physiological and behavioral patterns.
  • Therapeutic strategies focusing on circadian rhythm regulation, including light therapy, social rhythm management, and specific pharmacological agents, offer effective treatment options for depression.