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Updated: Jun 12, 2026

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

Published on: November 10, 2017

Upconversion nanoparticles in biological labeling, imaging, and therapy.

Feng Wang¹, Debapriya Banerjee, Yongsheng Liu

¹Department of Chemistry, Faculty of Science, National University of Singapore, 3 Science Drive 3, Singapore 117543.

|May 21, 2010

Summary

Upconversion nanoparticles offer advanced optical imaging and bio-detection. Their unique light-emitting properties enable sensitive biological applications with reduced sample damage.

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Area of Science:

Non-linear optics
Nanotechnology
Biomedical imaging

Background:

Upconversion converts low-energy photons to higher-energy ones.
Lanthanide-doped nanoparticles are increasingly used in biological sciences.
Upconversion nanoparticles offer advantages for bio-imaging and assays.

Purpose of the Study:

Review recent advancements in optical biolabeling and bio-imaging using upconversion nanoparticles.
Highlight the characteristics, strengths, and weaknesses of these nanomaterials.

Main Methods:

Review of literature on upconversion nanoparticle applications in biology.
Analysis of nanoparticle properties for bio-imaging and bio-detection.

Main Results:

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Last Updated: Jun 12, 2026

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

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Viral Nanoparticles for In vivo Tumor Imaging

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Upconversion nanoparticles are suitable for bio-detection, cancer therapy, and bio-imaging.
Near-infrared excitation offers deeper tissue penetration and less phototoxicity.
Intense visible emission under NIR excitation is advantageous for imaging.

Conclusions:

Upconversion nanoparticles are promising luminescent stains for bio-imaging.
Their small size, biocompatibility, and unique optical properties drive biological applications.
Further research is needed to fully leverage their potential and address limitations.