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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Video

Updated: Jun 12, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
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Bone histomorphometry: a concise review for endocrinologists and clinicians.

Carolina A Moreira Kulak1, David W Dempster

  • 1Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil. kulakjc@uol.com.br <kulakjc@uol.com.br>

Arquivos Brasileiros De Endocrinologia E Metabologia
|May 21, 2010
PubMed
Summary

Bone histomorphometry, a quantitative analysis of bone biopsies, provides crucial insights into bone structure and remodeling. This technique aids in diagnosing metabolic bone disorders and evaluating treatment effects.

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Area of Science:

  • Bone biology and metabolism
  • Skeletal pathology
  • Histology and histopathology

Background:

  • Bone histomorphometry is a quantitative histological examination of undecalcified bone biopsies.
  • It provides detailed information on bone remodeling and structure.
  • Labeling agents enable dynamic analysis of bone formation.

Purpose of the Study:

  • To diagnose subclinical osteomalacia.
  • To characterize renal osteodystrophy.
  • To investigate unexplained skeletal fragility.

Main Methods:

  • Quantitative histological examination of undecalcified bone biopsy.
  • Use of labeling agents for dynamic analysis of bone formation.
  • Categorization of parameters into structural, static remodeling, and dynamic remodeling subgroups.

Main Results:

  • Distinct histomorphometric profiles are observed in metabolic bone disorders like osteomalacia, hyperparathyroidism, hypothyroidism, osteoporosis, and renal osteodystrophy.
  • Antiresorptive and anabolic drugs induce characteristic changes detectable by bone histomorphometry.
  • Provides unique information on bone metabolism not obtainable through other methods.

Conclusions:

  • Bone histomorphometry is an essential research tool for understanding bone metabolism.
  • It offers unparalleled insights into bone structure and remodeling dynamics.
  • Crucial for diagnosing and characterizing various bone diseases and treatment responses.