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Updated: Jun 12, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

[Interdisciplinary recommendations for the treatment of metastatic renal cell carcinoma]

K Miller1, L Bergmann, P Albers

  • 1Klinik für Urologie, Charité - Universitätsmedizin Berlin. Kurt.miller@charite.de

Aktuelle Urologie
|May 21, 2010
PubMed

Insights

Targeted therapies have revolutionized metastatic renal cell carcinoma treatment, shifting focus from cytokines to new drugs like sunitinib and everolimus. An expert conference defined criteria for using these targeted agents and identified key research questions.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Metastatic renal cell carcinoma (mRCC) treatment has shifted from cytokine therapy to targeted agents.
  • Sunitinib, sorafenib, bevacizumab, and temsirolimus are established standards; everolimus was introduced in mid-2009.

Framework:

  • An interdisciplinary consensus conference convened to address the use of targeted therapies in mRCC.
  • The conference focused on treatment sequencing and identifying unanswered questions.

Implementation:

  • The 2009 conference built upon the findings of the 2008 meeting.
  • Results are presented as concise theses based on current study data.

Implications:

  • Establishes consensus on managing mRCC with novel targeted therapies.
  • Highlights critical areas for future research in renal cell carcinoma treatment.

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Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

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