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Updated: Jun 12, 2026
11:36
Glycan Node Analysis: A Bottom-up Approach to Glycomics
Published on: May 22, 2016
Normalized mass mapping of Orbitrap data to define complex, polyglycerol-based raw material compositions
Robert J Strife1, Michele L Mangels
1The Procter & Gamble Co., Global Analytical, Mason Business Center, 8700 Mason Montgomery Road, Mason, OH 45040, USA. strife.rj@pg.com
Rapid Communications in Mass Spectrometry : RCM
|May 21, 2010
Summary
Normalized Mass Mapping is a new technique for analyzing complex samples using Orbitrap mass spectrometry. This method offers accurate characterization of raw materials, potentially replacing traditional wet chemical analyses.
Area of Science:
- Analytical Chemistry
- Mass Spectrometry
- Polymer Science
Background:
- Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS) offers high resolution for complex sample analysis.
- Orbitrap mass spectrometers utilize Fourier transform methods but operate at lower resolutions (100,000) compared to FTICRMS.
- Characterizing complex raw materials like polyglycerol esters is crucial for industrial applications.
Purpose of the Study:
- To define and apply Normalized Mass Mapping for complex sample analysis using Orbitrap mass spectrometry.
- To assess the precision and accuracy of mass measurements for raw material characterization.
- To compare map-derived parameters with traditional wet-chemical methods.
Main Methods:
- Development of Normalized Mass Mapping for repeating oligomer units.
- Application of the method to polyglycerol ester raw material using Orbitrap mass spectrometry.
- Evaluation of mass measurement errors, achieving sub-parts per million (ppm) precision and accuracy.
Main Results:
- Normalized Mass Mapping successfully characterized a complex polyglycerol ester.
- Mass measurements demonstrated high precision and accuracy, critical for generating well-defined mass maps.
- Map-derived iodine values showed reasonable agreement with wet-chemical results.
Conclusions:
- Normalized Mass Mapping is a viable and accurate method for raw material characterization with Orbitrap mass spectrometry.
- The technique has the potential to replace conventional wet chemical methods in raw material control.
- This approach offers a powerful tool for analyzing complex polymeric materials.
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