Related Experiment Video
Updated: Jun 12, 2026
11:47
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
Plasma inflammatory mediators associated with bone metabolism in COPD
Jessica M Bon1, Yingze Zhang, Steven R Duncan
1Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA. bonjm@upmc.edu
COPD
|May 22, 2010
Summary
Systemic inflammatory mediators are linked to bone metabolism in patients with severe Chronic Obstructive Pulmonary Disease (COPD). These findings offer insights into osteoporosis risk factors and potential therapeutic targets for COPD-related bone disease.
Area of Science:
- Pulmonary Medicine
- Endocrinology
- Immunology
Background:
- The link between Chronic Obstructive Pulmonary Disease (COPD) and osteoporosis is recognized.
- However, the specific role of systemic inflammatory mediators in bone metabolism within COPD patients remains under-explored.
Purpose of the Study:
- To investigate the association between various systemic inflammatory mediators and markers of bone metabolism in severe COPD patients.
- To identify potential biological targets for managing bone disease in COPD.
Main Methods:
- Analysis of plasma samples from 40 COPD patients using multiplex protein arrays for 27 inflammatory mediators.
- Measurement of bone resorption (CTx) and bone formation (P1NP) using ELISA and radioimmunoassay, respectively.
- Statistical analysis to determine associations between mediators and bone markers, adjusting for steroid and bisphosphonate use.
Main Results:
- Ninety-five percent of participants exhibited low bone mineral density.
- Tumor necrosis factor alpha and interleukin 4 showed positive associations with both CTx and P1NP.
- RANTES and eotaxin were inversely associated with CTx and P1NP, while IL-2 and IFN-gamma correlated with P1NP.
Conclusions:
- Biologically relevant systemic mediators are associated with bone metabolism in severe COPD.
- These mediators may provide insights into the mechanisms of bone disease and serve as potential targets for biological therapies and disease monitoring.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:23Chronic Obstructive Pulmonary Disease II: Emphysema
Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
01:26COPD: Management Using Bronchodilators and Corticosteroids
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:20COPD: Pathogenesis and Clinical Features
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...